ChemInform Abstract: Discovery of GSK1997132B a Novel Centrally Penetrant Benzimidazole PPARγ Partial Agonist.

✍ Scribed by Mairi Sime; et al. et al.

• Book ID: 102071044
• Publisher: John Wiley and Sons
• Year: 2011
• Weight: 22 KB
• Volume: 43
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.201203200

✦ Synopsis

Abstract

Optimization of the PPARγ activity and in vivo pharmacokinetics of a non‐acidic benzimidazole derivative, identified as starting point for a centrally penetrant PPARγ partial agonist, leads to the identification of title compound (I), a potent and metabolically stable PPARγ partial agonist.