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ChemInform Abstract: Discovery of a Potent, Metabolically Stabilized Resorcylic Lactone as an Antiinflammatory Lead.

✍ Scribed by Y. Wang; et al. et al.

Publisher
John Wiley and Sons
Year
2010
Weight
19 KB
Volume
41
Category
Article
ISSN
0931-7597

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## Abstract Structure‐activity relationship studies lead to the discovery of compound (I), which shows potent ACAT inhibitory activity (IC~50~ = 12 nM) and good pharmacokinetic profile in mice.