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ChemInform Abstract: Discovery of a Novel Acyl-CoA: Cholesterol Acyltransferase Inhibitor: The Synthesis, Biological Evaluation, and Reduced Adrenal Toxicity of (4-Phenylcoumarin)acetanilide Derivatives with a Carboxylic Acid Moiety.

✍ Scribed by Masaki Ogino; et al. et al.

Book ID: 112043440
Publisher: John Wiley and Sons
Year: 2012
Weight: 40 KB
Volume: 43
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201217145

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ChemInform Abstract: Discovery of a Potent and Orally Available Acyl-CoA: Cholesterol Acyltransferase Inhibitor as an Antiatherosclerotic Agent: (4-Phenylcoumarin)acetanilide Derivatives.

✍ Masaki Ogino; et al. et al. 📂 Article 📅 2012 🏛 John Wiley and Sons ⚖ 21 KB 👁 1 views

## Abstract Structure‐activity relationship studies lead to the discovery of compound (I), which shows potent ACAT inhibitory activity (IC~50~ = 12 nM) and good pharmacokinetic profile in mice.