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ChemInform Abstract: Discovery and Synthesis of [6-Hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]- 2-(4-hydroxyphenyl)]benzo[b]thiophene: A Novel, Highly Potent, Selective Estrogen Receptor Modulator.

โœ Scribed by A. D. PALKOWITZ; A. L. GLASEBROOK; K. J. THRASHER; K. L. HAUSER; L. L. SHORT; D. L. PHILLIPS; B. S. MUEHL; M. SATO; P. K. SHETLER; G. J. CULLINAN; T. R. PELL; H. U. BRYANT

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
28
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Discovery and Synthesis of [6-Hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-2-(4hydroxyphenyl)]benzo[b]thiophene: A Novel, Highly Potent, Selective Estrogen Receptor Modulator.

-The title compound (V) displays greater estrogen antagonist potency in vitro in a human MCF-7 breast cancer cell proliferation assay and in vivo in uterine tissue than any known agent. In addition, (V) retains beneficial estrogen agonist actions on bone and lipid metabolism. -(PALKOWITZ, A. D.; GLASEBROOK, A.

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