ChemInform Abstract: Direct Asymmetric Intramolecular Alkylation of β-Alkoxy-α-amino Esters via Memory of Chirality.
✍ Scribed by Katsuhiko Moriyama; Hiroki Sakai; Takeo Kawabata
- Publisher
- John Wiley and Sons
- Year
- 2009
- Weight
- 48 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0931-7597
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Aziridine 2-Carboxylate Ester Mediated Asymmetric Synthesis of α-Alkyl β-Amino Acids. -Highly stereoselective reductive ring opening of the N-tosylaziridines (II) with LiAlH4 followed by oxidation of the syn-amino alcohols (III) provides an efficient entry to the asymmetric synthesis of αmethyl β-am
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