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ChemInform Abstract: Difluoromethylene Analogues of Aspartyl Phosphate: The First Synthetic Inhibitors of Aspartate Semi-Aldehyde Dehydrogenase.

✍ Scribed by Russell J. Cox; Andrea T. Hadfield; M. Belen Mayo-Martin

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
33
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

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Aspartyl Phosphonates and Phosphoramidates: The First Synthetic Inhibitors of Bacterial Aspartate-Semialdehyde Dehydrogenase
✍ Russell J. Cox; Jennifer S. Gibson; María Belén Mayo Martín 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 279 KB

The synthesis of methylene phosphonate, difluoromethylene phosphonate and phosphoramidate analogues of aspartyl phosphate, together with reduced analogues, is described. These compounds were shown to be effective inhibitors of aspartate-semialdehyde dehydrogenase (ASA-DH) from Escherichia coli. Howe