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Aspartyl Phosphonates and Phosphoramidates: The First Synthetic Inhibitors of Bacterial Aspartate-Semialdehyde Dehydrogenase.

✍ Scribed by Russell J. Cox; Jennifer S. Gibson; Maria Belen Mayo Martin

Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
33
Category
Article
ISSN
0931-7597

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Aspartyl Phosphonates and Phosphoramidat
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The synthesis of methylene phosphonate, difluoromethylene phosphonate and phosphoramidate analogues of aspartyl phosphate, together with reduced analogues, is described. These compounds were shown to be effective inhibitors of aspartate-semialdehyde dehydrogenase (ASA-DH) from Escherichia coli. Howe

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## Abstract __Unsaturated and fluorinated analogues of aspartyl‐β‐phosphate were synthesised as potential inhibitors of the bacterial enzyme aspartate semialdehyde dehydrogenase (ASA‐DH). Acetylenic and__ Z__‐olefinic analogues showed competitive inhibition, but an__ E__‐olefinic analogue was inact

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