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ChemInform Abstract: Dibasic Inhibitors of Human Mast Cell Tryptase. Part 3. Identification of a Series of Potent and Selective Inhibitors Containing the Benzamidine Functionality.

✍ Scribed by Jeffrey M. Dener; Kenneth D. Rice; William S. Newcomb; Vivian R. Wang; Wendy B. Young; Anthony R. Gangloff; Elaine Y.-L. Kuo; Lynne Cregar; Daun Putnam; Martin Wong


Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
32
Category
Article
ISSN
0931-7597

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ChemInform Abstract: 1,2-Benzisothiazol-
✍ Keith D. Combrink; H. Belgin Guelgeze; Nicholas A. Meanwell; Bradley C. Pearce; πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 29 KB πŸ‘ 2 views

From a library of 23 N-substituted title compounds, e.g. (I) and (II), derivative (Id) emerges as most potent and selective tryptase inhibitor besides derivatives (Ib) and (Ic). -(COMBRINK, KEITH D.; GUELGEZE,