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ChemInform Abstract: 1,2-Benzisothiazol-3-one 1,1-Dioxide Inhibitors of Human Mast Cell Tryptase.

✍ Scribed by Keith D. Combrink; H. Belgin Guelgeze; Nicholas A. Meanwell; Bradley C. Pearce; Pi Zulan; Gregory S. Bisacchi; Daniel G. M. Roberts; Paul Stanley; Steven M. Seiler

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

From a library of 23 N-substituted title compounds, e.g. (I) and (II), derivative (Id) emerges as most potent and selective tryptase inhibitor besides derivatives (Ib) and (Ic). -(COMBRINK, KEITH D.; GUELGEZE,

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