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ChemInform Abstract: Diastereoselectivity Switch in Cooperatively Catalyzed Three-Component Reactions of an Aryldiazoacetate, an Alcohol, and a β,γ-Unsaturated α-Keto Ester.

✍ Scribed by Jingjing Ji; Xia Zhang; Yingguang Zhu; Yu Qian; Jing Zhou; Liping Yang; Wenhao Hu


Publisher
John Wiley and Sons
Year
2011
Weight
60 KB
Volume
42
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Cooperative Catalys
✍ Xinfang Xu; Yu Qian; Liping Yang; Wenhao Hu 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 53 KB

## Abstract High diastereo‐ and enantioselectivities are observed in the three‐component Mannich‐type reaction of diazoacetophenone (I) with alcohol (III) and para‐ or meta‐substituted aromatic imines (II) using a Rh~2~(O‐Ac)~4~/BINOL‐derived chiral phosphoric acid catalyst combination.