ChemInform Abstract: Diastereomerically Pure 1,2-Diols by Nucleophilic Displacement Reactions of 3-Oxetanols — A Study Directed Towards the Identification of Suitable Nucleophiles and the Elucidation of Possible Side Reactions.

Diastereomerically Pure 1,2-Diols by Nuc

Diastereomerically Pure 1,2-Diols by Nucleophilic Displacement Reactions of 3-Oxetanols – A Study Directed Towards the Identification of Suitable Nucleophiles and the Elucidation of Possible Side Reactions

✍ Thorsten Bach; Frank Eilers 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 231 KB 👁 1 views

The ring opening of 3-isopropyl-2-phenyl-3-oxetanol (2a) by (42% yield) and 26 (54% yield). Other 2-phenyl-3-oxetanols such as 2b and 2c can also be employed as electrophiles, various nucleophiles has been studied. In the presence of BF 3 as a Lewis acid, a clean reaction at the less substituted C-4