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ChemInform Abstract: Diastereocontrol in the Synthesis of Models of Rings C and D of Phorbol: Directing Effect of an Ether Substituent on Lithium Carbenoid Mediated Cyclopropanation.

✍ Scribed by Michael G. B. Drew; Laurence M. Harwood; Antonio J. Macias-Sanchez; Richard Scott; R. M. Thomas; Daniel Uguen

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
32
Category
Article
ISSN
0931-7597

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Diastereocontrol in the Synthesis of Mod
Diastereocontrol in the Synthesis of Models of Rings C and D of Phorbol: Directing Effect of an Ether Substituent on Lithium Carbenoid Mediated Cyclopropanation
✍ Michael G. B. Drew; Laurence M. Harwood; Antonio J. Macías-Sánchez; Richard Scot 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 77 KB 👁 1 views

The diastereocomplementarity of halo- and alkylcarbenes (paths a and b, respectively) was shown in the cyclopropanation reaction of 1. The conversion of 1 into 7,7-dimethylbicyclo[4.1.0]heptan-1,2-diols (±)-2 and (±)-3 represents an important transformation in a synthetic strategy towards phorbol de