Diastereocontrol in the Synthesis of Mod
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Michael G. B. Drew; Laurence M. Harwood; Antonio J. Macías-Sánchez; Richard Scot
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Article
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2001
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John Wiley and Sons
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English
⚖ 77 KB
The diastereocomplementarity of halo- and alkylcarbenes (paths a and b, respectively) was shown in the cyclopropanation reaction of 1. The conversion of 1 into 7,7-dimethylbicyclo[4.1.0]heptan-1,2-diols (±)-2 and (±)-3 represents an important transformation in a synthetic strategy towards phorbol de