ChemInform Abstract: Design, Synthesis, and SAR of Amino Acid Derivatives as Factor Xa Inhibitors.
β Scribed by Ting Su; et al. et al.
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0931-7597
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The DE Novo Design and Synthesis of Cyclic Urea Inhibitors of Factor Xa: Initial SAR Studies. -A series of cyclic ureas is prepared and tested as inhibitors of the blood coagulation protein factor Xa. Molecular modelling calculations are performed to study the docking of the compounds to the factor