ChemInform Abstract: Design, Enantiopure Synthesis, and Biological Evaluation of Novel Iso-D-2′,3′-dideoxy-3′-fluorothianucleoside Derivatives as a Bioisostere of Lamivudine
✍ Scribed by Kyung Ran Kim; Ah-Young Park; Hyung Ryong Moon; Moon Woo Chun; Lak Shin Jeong
- Publisher
- John Wiley and Sons
- Year
- 2008
- Weight
- 15 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Title compounds (I) and their precursors are tested for antimicrobial activity against both Gram‐positive and Gram‐negative bacteria.
Synthesis and Biological Evaluation of a Series of 2'-Fluorinated-2',3'-dideoxy-2',3'-didehydro-(L)-nucleosides. -A general method for the synthesis of both the cis-and trans-2'-vinylfluoro containing nucleosides is presented. Among the nucleosides prepared compound (XI) displays the best biologica
## Abstract Six new pyridopyrimidinecarboxylate derivatives (XI) and (XIV) are synthesized, which all show significant antibacterial, antifungal and antitumor activities.