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ChemInform Abstract: Design and Synthesis of Bisubstrate Analogues for 3-Hydroxy-3-methyl- glutaryl Coenzyme A Reductase.

โœ Scribed by C. TAILLEFUMIER; D. DE FORNEL; Y. CHAPLEUR

Book ID
112034687
Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
27
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Design and Biologic
ChemInform Abstract: Design and Biological Evaluation of a Series of Thiophene-Based 3- Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors.
โœ G. M. COPPOLA; R. E. DAMON; H. YU; R. G. ENGSTROM; T. J. SCALLEN ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 34 KB ๐Ÿ‘ 1 views

Design and Biological Evaluation of a Series of Thiophene-Based 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors. -The target compounds (VII) are prepared starting from thiophenes (I) including aldol condensation and subsequent stereocontrolled reduction of the ฮฒ-ketoester function to giv