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ChemInform Abstract: Design and Synthesis of a New Type of Non-Steroidal Human Aromatase Inhibitors.

โœ Scribed by P. SONNET; ET AL. ET AL.

Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
29
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Evidence for New Non-Steroidal Human Aromatase Inhibitors and Comparison with Equine Aromatase Inhibition for an Understanding of the Mammalian Active Site.
โœ P. AUVRAY; S. MOSLEMI; P. SOURDAINE; S. GALOPIN; G.-E. SERALINI; C. ENGUEHARD; P ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 30 KB

Site. -Depending on the reaction time, indan-1-ones (III) and inden-1-ones (V) are prepared. They are further used to study the active binding site of human aromatase inhibitors. Two compounds (Vb) and (Vc) are good inhibitors of human aromatase whereas they weakly inhibit the equine enzyme.