The design as well as the synthesis, resolution, and biological evaluation of the neutral endopeptidase 24.11 inhibitors, (1S,2R,5S)-(-)-[(2-mercapto-5-phenyl-cyclopentanecarbonyl)amino]-acetic acid and (1R,2S,5R)-(+)- [(2-mercapto-5-phenyl-cyclopentanecarbonyl)-amino]-acetic acid are described.
ChemInform Abstract: Design and Synthesis of a New Class of Conformationally Constrained Inhibitors to Probe the Active Sites of Thermolysine and Neutral Endopeptidase 24.11.
β Scribed by E. FILLION; D. GRAVEL
- Book ID
- 112042141
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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Synthesis of a New Class of N-Linked Lewis and LacNAc Analogues as Potential Inhibitors of Human Fucosyltransferases: A General Method for the Incorporation of an Iminocyclitol as a Transition-State Mimetic of the Donor Sugar to the Acceptor. -The synthesis of the title N-linked di-and trisaccharid