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ChemInform Abstract: Convenient Preparation of 1-(Indol-3-yl)-2,2,2-trifluoroethylamines via Friedel—Crafts Reaction of α-Trifluoroacetaldehyde Hemiaminal.

✍ Scribed by Yuefa Gong; Katsuya Kato

Publisher: John Wiley and Sons
Year: 2010
Weight: 35 KB
Volume: 32
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200128118

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## Abstract The reaction proceeds highly selectively and might involve tandem condensation, nucleophilic addition and intramolecular 5‐exo‐cyclization.