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ChemInform Abstract: Convenient Catalytic Synthesis and Assignment of the Absolute Configuration of Enantiomerically Pure Dihydronaphthalenes and Their Corresponding Epoxides.

✍ Scribed by T. LINKER; F. REBIEN; G. TOTH; A. SIMON; J. KRAUS; G. BRINGMANN

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Convenient Catalytic Synthesis and Assignment of the Absolute Configuration of Enantiomerically Pure Dihydronaphthalenes and Their Corresponding Epoxides.

-The asymmetric epoxidation of known dihydronaphthalene derivative (I) is investigated in order to obtain enantiomerically pure epoxide (II), needed for the synthesis of lignans possessing anticancer activity. Kinetic resolution of racemic (I) is achieved by Jacobsen-Katsuki epoxidation. The absolute configurations of the products are established unequivocally by comparison of experimental and quantumchemically calculated (AM1, PM3) CD spectra. -(LINKER, T.; REBIEN,

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