Retro-Ene Reaction. Part 5. Functionalization of 4,5-Dihalopyridazin-6-ones Using 1-Hydroxymethyl-4,5-dihalopyridazin-6-ones as 1-O, 3-N, 5-O Ene Adducts. -Functionalization of title compounds (I) via a retro-ene reaction with some nucleophiles affords exclusively 4-halo substituted products such
ChemInform Abstract: Concurrent Alkylation-Methoxylation of 4,5-Dihalopyridazin-6-ones and Synthesis of 5-Halo-4-hydroxypyridazin-6-ones.
โ Scribed by S.-D. CHO; W.-Y. CHOI; Y.-J. YOON
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Retro-Ene Reaction. Part 6. Functionalization of 4,5-Dihalopyridazin-6-ones Using 1-Acetyloxymethyl-4,5-dihalopyridazin-6-ones as the 1-O, 3-N, 5-O Ene-Adduct. -The synthesis and storage of the known 1-hydroxymethyl derivative of (I) is difficult. Thus, the functionalization of 4,5-dihalopyridazin-
Dehalogenation of 1-Methyl-5-halo-4-substituted-pyridazin-6-ones. -In connection with another study, the title reaction is investigated in more detail. It is noteworthy that the nature of the halogen atom (Cl or Br) does not influence the results. In the case of (III) an enhanced amount of Pd-C lea