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ChemInform Abstract: CC-1065 and the Duocarmycins: Synthetic Studies

โœ Scribed by D. L. BOGER; C. W. BOYCE; R. M. GARBACCIO; J. A. GOLDBERG

Book ID
101848052
Publisher
John Wiley and Sons
Year
2010
Weight
24 KB
Volume
28
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Enzymatic Preparati
ChemInform Abstract: Enzymatic Preparation of an Optically Active Precursor of the CC-1065/ Duocarmycin Pharmacophore.
โœ R. CHENEVERT; G. COURCHESNE ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 31 KB ๐Ÿ‘ 2 views

Enzymatic Preparation of an Optically Active Precursor of the CC-1065/ Duocarmycin Pharmacophore. -Both enantiomers of the monoacetate (III) are synthesized via enzymatic desymmetrization of propanediol (I). Incorporation of these optically active monoacetates into the established synthetic routes