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ChemInform Abstract: Catalytic Enantioselective Addition of Diethylzinc to (Hetero)Aromatic Aldehydes.

✍ Scribed by I. IOVEL; G. OEHME; E. LUKEVICS

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

1998 stereochemistry stereochemistry (general, optical resolution) O 0030

48 -025

Catalytic Enantioselective Addition of Diethylzinc to (Hetero)Aromatic Aldehydes.

-The title investigation is presented with a view to the importance of enantiomerically pure (hetero)aryl alcohols in organic synthesis. N,N-Dibutyl-D-norephedrine is found to be a better catalyst for the enantioselective alkylation than (S)-2-aminobutanol. Alcohols (Vb) and (Vd) are prepared for the first time by catalytic asymmetric alkylation. -

πŸ“œ SIMILAR VOLUMES

Catalytic enantioselective addition of d
Catalytic enantioselective addition of diethylzinc to (hetero)aromatic aldehydes
✍ Irina Iovel; GΓΌnther Oehme; Edmunds Lukevics πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 92 KB πŸ‘ 1 views

The asymmetric alkylation with diethylzinc of five heterocyclic aldehydes and benzaldehyde (for comparison) has been studied in the presence of two optically active amino alcohols: (S)-2-amino-1-butanol (AB) and (1S,2R)-N,Ndibutylnorephedrine (DBNE). A number of chiral (hetero)aromatic secondary alc