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ChemInform Abstract: Catalytic Asymmetric Aminohydroxylation with Amino-Substituted Heterocycles as Nitrogen Sources.

โœ Scribed by Lukas J. Goossen; Hong Liu; K. Ruprecht Dress; K. Barry Sharpless

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
30
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Catalytic Asymmetric Aminohydroxylation with Amino-Substituted Heterocycles as Nitrogen Sources.

-It is found that simple aminopyrimidines and aminotriazines (Ia) and (Ic) function as excellent N-sources for the title reaction of a number of representative olefins to afford N-protected amino alcohols in enantiomeric excesses of 56 to 97%. For all unsymmetrical olefins, a strong preference for the isomer with nitrogen in the benzylic position is observed. - (GOOSSEN,

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