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ChemInform Abstract: C(2)-Functionalization of 1-Substituted Imidazoles with Cyanoacetylenes and Aromatic or Heteroaromatic Aldehydes.

โœ Scribed by Boris A. Trofimov; et al. et al.


Publisher
John Wiley and Sons
Year
2011
Weight
39 KB
Volume
42
Category
Article
ISSN
0931-7597

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C2-Functionalization of 1-Substituted Im
โœ Boris A. Trofimov; Ludmila V. Andriyankova; Kseniya V. Belyaeva; Anastasiya G. M ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 342 KB

## Abstract A novel threeโ€component reaction between 1โ€substituted imidazoles, aldehydes, and electronโ€deficient acetylenes proceeds under mild conditions (20โ€“25 ยฐC, no catalyst, no solvent) to form an unknown family of C2โ€functionalized imidazoles in up to 74โ€‰% yield, the function constituting a p