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ChemInform Abstract: C- or O-Alkylation of 5-Ethoxycarbonyl-2-hydroxymethyl Pyridine with Arylmethane Derivatives.

✍ Scribed by C. BISSANTZ; P. BISEL; G. SCHLEWER

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

C-or O-Alkylation of 5-Ethoxycarbonyl-2-hydroxymethyl Pyridine with Arylmethane Derivatives.

-In connection with a research on neurotransmitter inhibitory active compounds, alkylation of pyridine derivative (I) is investigated. Thus, NaH-mediated reaction with diaryl bromomethanes (II) gives the C-alkylation products (III), whereas the benzylbromides (IV) lead to exclusive O-alkylation under the same conditions. O-Diarylmethylated compounds [cf. (VII)] are easily obtained by acidic etherification of (I) with alcohols of type (VI).

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