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ChemInform Abstract: Biogenetically Patterned Synthesis of Camptothecin and 20-Deoxycamptothecin.

โœ Scribed by Richard T. Brown; Liu Jianli; Cid A. M. Santos

Publisher
John Wiley and Sons
Year
2010
Weight
24 KB
Volume
31
Category
Article
ISSN
0931-7597

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## 2. Synthesis and in vitro Cytotoxicity of 5-C-Substituted 20(S)-Camptothecin Analogues. -A series of several 5-substituted camptothecin analogues [cf. (II), (IV), (VI)] are synthesized from the natural alkaloid (I) and evaluated for their in vitro anticancer activity. Some of these analogues, e