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ChemInform Abstract: Benzofuro[3,2-b]pyridines as Mixed ETA/ETB and Selective ETB Endothelin Receptor Antagonists.

✍ Scribed by Werner W. K. R. Mederski; Mathias Osswald; Dieter Dorsch; Maria Christadler; Claus-Jochen Schmitges; Claudia Wilm

Publisher: John Wiley and Sons
Year: 2010
Weight: 35 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199926150

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✦ Synopsis

Benzofuro[3,

pyridines as Mixed ET A /ET B and Selective ET B Endothelin Receptor Antagonists.

-A series of title compounds, e.g. (IX), is prepared and tested for the desired endothelin receptor antagonistic activity. The general synthetic method is described for compound (VIII) showing moderate activity. The most potent non-selective antagonist is found to be derivative (IXa) whereas (IXb) shows selective ET B inhibitory activity.

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