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ChemInform Abstract: Benzo(c)quinoliziniums: A New Family of Inhibitors for Protein Kinase CKII

โœ Scribed by Y. METTEY; J.-M. VIERFOND; M. BAUDRY; C. COCHET; D. SARROUILHE

Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
28
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis and Protein Kinase C Inhibitory Activities of Acyclic Balanol Analogues That are Highly Selective for Protein Kinase C Over Protein Kinase A.
โœ J. M. DEFAUW; M. M. MURPHY; G. E. JUN. JAGDMANN; H. HU; J. W. LAMPE; S. P. HOLLI ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 31 KB ๐Ÿ‘ 2 views

A series of analogues of balanol (I) in which the perhydroazepine ring and the p-hydroxybenzamide moiety have been combined into a simple acyclic linked unit are evaluated for their inhibitory properties. It is found that a three-carbon linkage is optimal. Substitution on the three-carbon chain is i