## Abstract magnified image Benzo‐fused heterocyclic and carbocyclic systems have been synthesized by intramolecular S~N~Ar and tandem S~N~2‐S~N~Ar reactions. Treatment of 3‐(2‐fluoro‐5‐nitrophenyl)‐1‐propanol with sodium hydride in __N,N__‐dimethylformamide gave 6‐nitrochroman in 80% yield by an
✦ LIBER ✦
ChemInform Abstract: Benzo-Fused Heterocycles and Carbocycles by Intramolecular SNAr and Tandem SN2-SNAr Reactions.
✍ Scribed by Richard A. Bunce; Takahiro Nago; Nathan Sonobe; LeGrande M. Slaughter
- Publisher
- John Wiley and Sons
- Year
- 2008
- Weight
- 29 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0931-7597
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## Abstract A tandem S~N~2‐Michael addition reaction has been developed for the synthesis of __cis__‐ and __trans__‐fused nitrogen and sulfur heterocycles from the __cis__ and __trans__ isomers of ethyl (±)‐(2__E__)‐3‐[2‐(iodomethyl)cyclo‐hexyl]‐2‐propenoate. Octahydro‐1__H__‐isoindole‐1‐acetic aci