ChemInform Abstract: Asymmetric Synthesis of β-Substituted γ-Lactams via Rhodium/Diene-Catalyzed 1,4-Additions: Application to the Synthesis of (R)-Baclofen (V) and (R)-Rolipram (IV).

ChemInform Abstract: Enantioselective Sy

ChemInform Abstract: Enantioselective Synthesis of β-Substituted Butyric Acid Derivatives via Orthoester Claisen Rearrangement of Enzymatically Resolved Allylic Alcohols: Application to the Synthesis of (R)-(-)-Baclofen.

✍ E. BRENNA; N. CARACCIA; C. FUGANTI; C. FUGANTI; D. FUGANTI; P. GRASSELLI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB 👁 1 views

Enantioselective Synthesis of β-Substituted Butyric Acid Derivatives via Orthoester Claisen Rearrangement of Enzymatically Resolved Allylic Alcohols: Application to the Synthesis of (R)-(-)-Baclofen. -A three step synthesis of the GABA B receptor agonist (-)-baclofen is presented. Key step in this