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ChemInform Abstract: Asymmetric Synthesis of BB-3497 — A Potent Peptide Deformylase Inhibitor.

✍ Scribed by Lisa M. Pratt; R. Paul Beckett; Stephen J. Davies; Steven B. Launchbury; Andrew Miller; Zoe M. Spavold; Richard S. Todd; Mark Whittaker

Publisher: John Wiley and Sons
Year: 2010
Weight: 34 KB
Volume: 33
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200201202

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Synthesis of CMI-977, a Potent 5-Lipoxygenase Inhibitor. -A facile large-scale synthesis of the potent 5-lipoxygenase inhibitor CMI-977 (XI) in enantiomerically pure form starting from hydroxymethyl-γ-butyrolactone (I) derived from (S)-glutamic acid is described (yields given in g). -(CAI,