ChemInform Abstract: Asymmetric Dihydroxylation onto the α,β-Unsaturated Carboxylic Ester Derivatives of Camptothecin.

✍ Scribed by K. TAGAMI; S. TAKAGI; S. SANO; M. SHIRO; Y. NAGAO

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 37 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199807090

✦ Synopsis

Asymmetric Dihydroxylation onto the α,β-Unsaturated Carboxylic Ester Derivatives of Camptothecin.

-The title investigation is presented in context with studies on the preparation of camptothecin derivatives applicable as clinical antitumor agents. Compounds (IIa) and (IIIa) exhibit strong antitumor activities against p388 lymphocytic leukemia inoculated into mice. The absolute configurations of the dihydroxylation products are determined by chemical correlation. -(TAGAMI, K.;