ChemInform Abstract: Ascorbate Mediated Copper Catalyzed Reductive Cross-Coupling of Disulfides with Aryl Iodides.
β Scribed by Marek Martinek; Michal Korf; Jiri Srogl
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 39 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
Sodium ascorbate is presented as a mild and environmentally benign reducing agent to keep the metal catalyst in the title reaction in its reduced, active form.
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## Abstract A copperβcatalyzed crossβcoupling reaction of alkynes with aryl iodides is described. The system tolerates a broad range of functional groups and enables the use of sterically demanding substrates with only 1.0β2.5 molβ% of Cu~2~O and 1.0β2.5 molβ% of xantphos as the catalyst.