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ChemInform Abstract: (Aryloxy)methylsilane Derivatives as New Cholesterol Biosynthesis Inhibitors: Synthesis and Hypocholesterolemic Activity of a New Class of Squalene Epoxidase Inhibitors.

โœ Scribed by J.-P. GOTTELAND; I. BRUNEL; F. GENDRE; J. DESIRE; A. DELHON; D. JUNQUERO; P. OMS; S. HALAZY


Book ID
112024193
Publisher
John Wiley and Sons
Year
2010
Weight
36 KB
Volume
26
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Sulfonamide Derivat
โœ J.-P. GOTTELAND; C. LOUBAT; B. PLANTY; D. JUNQUERO; A. DELHON; S. HALAZY ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 36 KB ๐Ÿ‘ 1 views

Sulfonamide Derivatives of Benzylamine Block Cholesterol Biosynthesis in HepG 2 Cells: A New Type of Potent Squalene Epoxidase Inhibitors. -A new class of sulfonamide derivatives (VI) which act as mammalian squalene epoxidase inhibitors is synthesized. It is shown that thienyl residue is necessary