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ChemInform Abstract: Antiplasmodial and Antitumor Activity of Dihydroartemisinin Analogues Derived via the Aza-Michael Addition Reaction.

โœ Scribed by Tzu-Shean Feng; Eric M. Guantai; Margo J. Nell; Constance E. J. van Rensburg; Heinrich C. Hoppe; Kelly Chibale

Publisher
John Wiley and Sons
Year
2011
Weight
29 KB
Volume
42
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Abstract

The azaโ€Michael reaction of 10ฮฑโ€ and 10ฮฒโ€dihydroartemisinin acrylates, respectively with amines and chloroquinoline amines gives access to novel artemisinin analogues (I) and (II) whose antiplasmodial and antitumor activity is evaluated.

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