ChemInform Abstract: Amine-Catalyzed Direct Asymmetric Mannich-Type Reactions.
β Scribed by Wolfgang Notz; Kandasamy Sakthivel; Tommy Bui; Guofu Zhong; Carlos F. Barbas III
- Publisher
- John Wiley and Sons
- Year
- 2001
- Weight
- 32 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0931-7597
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## Abstract **Taking the reins**: The title transformation of thioamides and __N__βdiphenylphosphinoyl imines is described. By harnessing the power of cooperative catalysis between a soft Lewis acid and a hard BrΓΈnsted base, thioamide carbon pronucleophiles can furnish Mannich products (see scheme)