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ChemInform Abstract: Advances in the Methodology of a Multicomponent Synthesis of Arylnaphthalene Lactones.

โœ Scribed by Patrick Foley; Nicolas Eghbali; Paul T. Anastas

Publisher
John Wiley and Sons
Year
2010
Weight
26 KB
Volume
41
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Abstract

A multicomponent synthesis of arylnaphthalene lignan lactones is developed and successfully applied to the preparation of the natural products dehydrodimethylretroconidendrin (IV) and its regioisomer (V).

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## Abstract Etoposide and tenoposide, derivatives of the aryltetralin lignan lactone podophyllotoxin (**5**), are clinically important anticancer agents. The structure of podophyllotoxin includes four contiguous chiral centres contained within a stereochemically unstable __trans__โ€fused tetrahydron