ChemInform Abstract: Acid-Catalyzed Rearrangement of 3-(β-2-Aminostyryl)quinoxalin-2(1H)ones — A New and Efficient Method for the Synthesis of 2-Benzimidazol-2-ylquinolines.
✍ Scribed by Vakhid A. Mamedov; Dina F. Saifina; Aidar T. Gubaidullin; Venera R. Ganieva; Saniya F. Kadyrova; Dimitry V. Rakov; Il'dar Kh. Rizvanov; Oleg G. Sinyashin
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 26 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
A convenient one‐pot approach to the important pharmacore includes the initial reduction of the nitro group and subsequent acid‐induced rearrangement via a novel ring contraction.
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A New and Efficient Synthesis of Phthalazin-1(2H)-ones. -Treating readily available ethers (III) with catalytic acid under dry conditions provides an efficient synthesis of phthalazin-1(2H)-ones (IV). Using moist solvents results in hydrolysis [cf. (V)]. Treatment of (IIIa) with catalytic AlCl 3 lea
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