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ChemInform Abstract: Acetogenic Isoquinoline Alkaloids. Part 88. Antiprotozoal Activity of Naphthylisoquinoline Alkaloids. Part 7. Synthesis of Pindikamine A, a Michellamine-Related Dimer of a Non-Natural, “Skew” Naphthylisoquinoline.

✍ Scribed by G. BRINGMANN; R. GOETZ; G. FRANCOIS

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

Acetogenic Isoquinoline Alkaloids. Part 88. Antiprotozoal Activity of Naphthylisoquinoline Alkaloids. Part 7. Synthesis of Pindikamine A, a Michellamine-Related Dimer of a Non-Natural, "Skew" Naphthylisoquinoline.

-The first preparation of a non-natural (skew, since 6,8'-coupled) naphthylisoquinoline (cf. (IV)) and its oxidative coupling to furnish the novel dimeric naphthylisoquinoline pindikamine A (VI), which represents the first michellamine analogue without axial chirality, is described. The title compound (VI) and its monomeric "half" exhibit good antimalarial activity against Plasmodium falciparum in vitro.

-(BRINGMANN, G.;

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