ChemInform Abstract: Ab initio Polypeptide Structure Prediction
โ Scribed by Philippe Derreumaux
- Publisher
- John Wiley and Sons
- Year
- 2000
- Weight
- 23 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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As part of the third Critical Assessment of Structure Prediction meeting (CASP3), we predict the three-dimensional structures for 13 proteins using a hierarchical approach. First, all possible compact conformations of a protein sequence are enumerated using a highly simplified tetrahedral lattice mo
To generate structures consistent with both the local and nonlocal interactions responsible for protein stability, 3 and 9 residue fragments of known structures with local sequences similar to the target sequence were assembled into complete tertiary structures using a Monte Carlo simulated annealin