As part of the third Critical Assessment of Structure Prediction meeting (CASP3), we predict the three-dimensional structures for 13 proteins using a hierarchical approach. First, all possible compact conformations of a protein sequence are enumerated using a highly simplified tetrahedral lattice mo
Ab initio protein structure prediction using pathway models
β Scribed by Xin Yuan; Yu Shao; Christopher Bystroff
- Publisher
- Hindawi Publishing Corporation
- Year
- 2003
- Tongue
- English
- Weight
- 416 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1531-6912
- DOI
- 10.1002/cfg.305
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
To generate structures consistent with both the local and nonlocal interactions responsible for protein stability, 3 and 9 residue fragments of known structures with local sequences similar to the target sequence were assembled into complete tertiary structures using a Monte Carlo simulated annealin
We discuss how methods based on hidden Markov models performed in the fold-recognition section of the CASP2 experiment. Hidden Markov models were built for a representative set of just over 1,000 structures from the Protein Data Bank (PDB). Each CASP2 target sequence was scored against this library
## Abstract Recently __ab initio__ protein structure prediction methods have advanced sufficiently so that they often assemble the correct low resolution structure of the protein. To enhance the speed of conformational search, many __ab initio__ prediction programs adopt a reduced protein represent
Structure predictions for nine targets from the CASP3 meeting are presented and compared with the experimental structure. These predictions are made using the simplified flexible geometry representation of protein structure and potentials which mimic the physical forces involved in protein folding w