ChemInform Abstract: A Versatile Preparation of 2-Methyleneoxetanes.
β Scribed by L. M. DOLLINGER; A. R. HOWELL
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 28 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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A 2-Methyleneoxetane Analogue of Orlistat Demonstrating Inhibition of Porcine Pancreatic Lipase. -A novel analogue (IIIc) of orlistat is created by substitution of the carbonyl group in (Ic) by a methylene unit. Although the carbonyl group seems to be important for porcine pancreatic lipase inhibit