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ChemInform Abstract: A 2-Methyleneoxetane Analogue of Orlistat Demonstrating Inhibition of Porcine Pancreatic Lipase.

✍ Scribed by L. M. DOLLINGER; A. R. HOWELL

Publisher: John Wiley and Sons
Year: 2010
Weight: 28 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199832140

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✦ Synopsis

A 2-Methyleneoxetane Analogue of Orlistat Demonstrating Inhibition of Porcine Pancreatic Lipase.

-A novel analogue (IIIc) of orlistat is created by substitution of the carbonyl group in (Ic) by a methylene unit. Although the carbonyl group seems to be important for porcine pancreatic lipase inhibitory activity, (IIIc) shows comparable activity to orlistat.

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