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ChemInform Abstract: A Tricyclic Template Derived from (2S,4R)-4-Hydroxyproline for the Synthesis of Protein Loop Mimetics.

✍ Scribed by R. BEELI; M. STEGER; A. LINDEN; J. A. ROBINSON

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199711187

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✦ Synopsis

A Tricyclic Template Derived from (2S,4R)-4-Hydroxyproline for the Synthesis of Protein Loop Mimetics.

-Starting from (2S,4R)-4hydroxyproline the tricyclic diketopiperazine ( VI) is synthesized. This template has carboxy and amino groups to which a peptide chain may be attached. By investigations with the incorporation of a cyclic peptide it is shown that this novel template may be used in the synthesis of cyclic peptide and protein mimetics having defined secondary structure in aqueous environments.

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