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ChemInform Abstract: A Simple Synthesis of 1-Substituted 5-Aminopyrazoles and Pyrazolo[1,5-a]-s-triazine Derivative.

✍ Scribed by Y. YAMADA; H. YASUDA; K. YOSHIZAWA

Publisher: John Wiley and Sons
Year: 2010
Weight: 28 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199907140

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✦ Synopsis

A Simple Synthesis of 1-Substituted 5-Aminopyrazoles and Pyrazolo[1,5-a]-s-triazine Derivative.

-The title compounds (III) are synthesized directly by cyclization of hydrazine derivatives (II) with (E)-2,3-dicyano-butendioates (I) in the presence of organic salts. The reaction is assumed to proceed via Michael addition of (II) to (I). The resulting adduct undergoes cyclization by nucleophilic attack to a cyano group to give the pyrazole ring with elimination of hydrogen cyanide and imine-enamine tautomerization.

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## Abstract For Abstract see ChemInform Abstract in Full Text.

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