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ChemInform Abstract: A Short Synthesis of an Important Precursor to a New Class of Bicyclic β-Lactamase Inhibitors.

✍ Scribed by J. R. BELLETTINI; M. J. MILLER


Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
28
Category
Article
ISSN
0931-7597

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ChemInform Abstract: A Short Synthesis o
✍ Braj B. Lohray; Sundarababu Baskaran; B. Srinivasa Rao; B. Yadi Reddy; I. Negesw 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB

Starting from the D-mannitol derivative (I), a straightforward synthesis of the chiral oxazolidines (VII) including precursors (VIIb) and (VIIc) of linezolid and eperezolid is detailed. Furthermore, the azide (VIIb) is converted to linezolid (IX) with thioacetic acid.