ChemInform Abstract: A Short Enantioselective Synthetic Route to (+)-Cassiol.

✍ Scribed by S. MAITI; B. ACHARI; A. K. BANERJEE

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199823226

✦ Synopsis

A Short Enantioselective Synthetic Route to (+)-Cassiol.

-Cyclohexenone derivative (VI), a key intermediate for the preparation of (+)-cassiol (VII), is synthesized starting from β-methylpropionylacetate (I) by condensation with chiral amine (II) followed by asymmetric Michael reaction with acrolein, hydrolysis and cyclization to produce the chiral cyclohexenone (V). This is converted to the silyl derivative (VI), which can be transformed to title compound in three steps.