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ChemInform Abstract: A Remarkable Titanium-Catalyzed Asymmetric Strecker Reaction Using Hydrogen Cyanide at Room Temperature.

✍ Scribed by Balamurugan Ramalingam; Abdul Majeed Seayad; Li Chuanzhao; Marc Garland; Kazuhiko Yoshinaga; Manabu Wadamoto; Takushi Nagata; Christina L. L. Chai

Publisher: John Wiley and Sons
Year: 2011
Weight: 39 KB
Volume: 42
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201107023

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✦ Synopsis

Abstract

Partially hydrolyzed titanium butoxide in combination with a chiral phenol ligand and TmsCN are employed as catalyst system for the title reaction.

📜 SIMILAR VOLUMES

A Remarkable Titanium-Catalyzed Asymmetr

A Remarkable Titanium-Catalyzed Asymmetric Strecker Reaction using Hydrogen Cyanide at Room Temperature

✍ Balamurugan Ramalingam; Abdul Majeed Seayad; Li Chuanzhao; Marc Garland; Kazuhik 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 369 KB

## Abstract Close to perfect enantioselectivity (up to 98% __ee__) is obtained for the formation of amino nitriles using hydrogen cyanide (HCN) as the cyanide source at room temperature for the first time. In an operationally simple process, the catalyst generated from a partially hydrolyzed titani