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A Remarkable Titanium-Catalyzed Asymmetric Strecker Reaction using Hydrogen Cyanide at Room Temperature

✍ Scribed by Balamurugan Ramalingam; Abdul Majeed Seayad; Li Chuanzhao; Marc Garland; Kazuhiko Yoshinaga; Manabu Wadamoto; Takushi Nagata; Christina L. L. Chai

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 369 KB
Volume: 352
Category: Article
ISSN: 1615-4150
DOI: 10.1002/adsc.201000462

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✦ Synopsis

Abstract

Close to perfect enantioselectivity (up to 98% ee) is obtained for the formation of amino nitriles using hydrogen cyanide (HCN) as the cyanide source at room temperature for the first time. In an operationally simple process, the catalyst generated from a partially hydrolyzed titanium alkoxide (PHTA) and (S)‐N‐salicyl‐β‐amino alcohol ligand, catalyzes the cyanation of imines in a short reaction time.

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ChemInform Abstract: A Remarkable Titani

ChemInform Abstract: A Remarkable Titanium-Catalyzed Asymmetric Strecker Reaction Using Hydrogen Cyanide at Room Temperature.

✍ Balamurugan Ramalingam; Abdul Majeed Seayad; Li Chuanzhao; Marc Garland; Kazuhik 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 39 KB 👁 2 views

## Abstract Partially hydrolyzed titanium butoxide in combination with a chiral phenol ligand and TmsCN are employed as catalyst system for the title reaction.